去甲腎上腺素轉運體 

去甲腎上腺素轉運體
識別號
别名SLC6A2;, NAT1, NET, NET1, SLC6A5, solute carrier family 6 member 2, Norepinephrine transporter, norepinephrine transporter gene
外部IDOMIM163970 MGI1270850 HomoloGene816 GeneCardsSLC6A2
為以下藥物的標靶
阿米替林、​阿莫沙平、​阿托莫西汀、​丁氨苯丙酮、​西酞普兰、​氯米帕明、​地昔帕明、​去甲文拉法辛、​右旋安非他命、​度洛西汀、​丙咪嗪、​左旋米那普倫、​洛非帕明、​马普替林、​馬吲哚、​哌甲酯、​奈法唑酮、​nisoxetine、​(RS)-nomifensine、​去甲替林、​苯乙肼、​普罗替林、​喹硫平、​esreboxetine、​西布曲明、​他噴他竇、​曲米帕明、​文拉法辛、​zotepine、​serdexmethylphenidate chloride、​右旋哌甲酯、​右旋安非他命、​苯丙胺、​liafensine、​甲基苯丙胺、​phentermine hydrochloride、​安非拉酮、​去甲文拉法辛、​馬吲哚、​伪麻黄碱、​methylphenidate hydrochloride、​dasotraline、​milnacipran、​diethylpropion hydrochloride、​bretylium tosylate、​desipramine hydrochloride、​guanadrel sulfate、​imipramine hydrochloride、​nefazodone hydrochloride、​orphenadrine citrate、​phenmetrazine hydrochloride、​protriptyline hydrochloride、​(+)-pseudoephedrine hydrochloride、​venlafaxine hydrochloride[1]
基因位置(人类
16號染色體
染色体16號染色體[2]
16號染色體
去甲腎上腺素轉運體的基因位置
去甲腎上腺素轉運體的基因位置
基因座16q12.2起始55,655,988 bp[2]
终止55,707,645 bp[2]
RNA表达模式




查阅更多表达数据
直系同源
物種人類小鼠
Entrez
Ensembl
UniProt
mRNA​序列

NM_001043
​NM_001172501
​NM_001172502
​NM_001172504

NM_009209

蛋白序列

NP_001034
​NP_001165972
​NP_001165973
​NP_001165975

NP_033235

基因位置​(UCSC)Chr 16: 55.66 – 55.71 MbChr 8: 93.69 – 93.73 Mb
PubMed​查找[4][5]
維基數據
檢視/編輯人類檢視/編輯小鼠

去甲腎上腺素轉運體(英語:Norepinephrine_transporterNET),也被稱為溶質載體家族6成員2(英語:solute carrier family 6 member 2SLC6A2),是由SLC6A2基因編碼的蛋白質[6]。NET是一种單胺轉運體英语monoamine transporter,負責依賴Na+/Cl的胞外去甲腎上腺素再攝取。NET也可轉運多巴胺。對這兩種神经递质的再吸收是調控突觸間隙英语synaptic cleft傳導物濃度的重要機制。

NET以及其他單胺轉運體是不少抗抑鬱劑以及娛樂性藥物的作用對象。過少的NET跟直立不耐症英语orthostatic intolerance相關,過多NET則和ADHD相關。[7][8]


  1. ^ 對Solute carrier family 6 member 2起作用的藥物;在維基數據上查看/編輯參考. 
  2. ^ 2.0 2.1 2.2 GRCh38: Ensembl release 89: ENSG00000103546 - Ensembl, May 2017
  3. ^ 3.0 3.1 3.2 GRCm38: Ensembl release 89: ENSMUSG00000055368 - Ensembl, May 2017
  4. ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  5. ^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. 
  6. ^ Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. Mar 1991, 350 (6316): 350–4. PMID 2008212. doi:10.1038/350350a0. 
  7. ^ Schroeter S, Apparsundaram S, Wiley RG, Miner LH, Sesack SR, Blakely RD. Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter. The Journal of Comparative Neurology. May 2000, 420 (2): 211–32. PMID 10753308. doi:10.1002/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3. 
  8. ^ Tellioglu T, Robertson D. Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications. Expert Reviews in Molecular Medicine. Nov 2001, 2001 (29): 1–10. PMID 14987367. doi:10.1017/S1462399401003878. 



取材自維基百科 - 中文時事百科